Members of the TRR259

Research Area A

Non-resident mechanisms of aortic and aortic valve disease

The Research area A (systemic, non-resident mechanisms) comprises factors, signals, and cells (such as leukocytes, red blood cells, platelets, and adipocytes) and their respective messengers, that are not originating from or residing in aortic tissue. We have divided this area into an inflammatory and a non-inflammatory section.

Research Area B

Resident mechanisms of aortic and aortic valve disease

The Research area B (Resident mechanisms) covers processes initiated or caused by pathways within or between resident cells (section 1) and the ECM (section 2).

Research Area C

The ultimate goal of the consortium is to improve prevention, detection and treatment of aortic disease. For this, translation of preclinical findings to patient care is essential and requires primary cells, cell organoids, small and large animal models, as well as human studies in order to holistically perform disease modelling, disease phenotyping, diagnostics, risk stratification and therapeutic interventions. Projects in research area C are dedicated to this translational focus. 

Research Area D