Chronic kidney disease (CKD) is an independent risk factor for the development of coronary artery disease (CAD). For both, CKD and CAD, the intercellular transfer of microRNAs (miR) through extracellular vesicles (EVs) is an important factor of disease development. Whether the combination of CAD and CKD affects endothelial function through cellular crosstalk of EV-incorporated miRs is still unknown.
The group of Andreas Zietzer et. al. could shown in this paper that EV-miR-mediated vascular intercellular communication is altered in patients with CAD and CKD, promoting CKD-induced endothelial dysfunction.
Publication about an altered intercellular communication mediated by MicroRNA in chronic kidney diseases Altered intercellular communication mediated by MicroRNA in chronic kidney diseases
November 02, 2020
MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease