The Department of Internal Medicine II from the University Bonn published a new paper about microRNAs (miRNAs) as master regulators of atherosclerosis. Cardiovascular disease remains the major cause of morbidity and mortality worldwide. There are indications that atherosclerosis and its sequelae, coronary artery disease, contribute to the majority of cardiovascular death. It was shown that small RNAs, especially micro RNAs (miRNAs) are dynamic regulators of disease pathogenesis. They are considered to be central during the regulation of gene expression through numerous mechanisms and provide a means to develop biomarkers and therapeutic tools for the diagnosis and therapy of atherosclerosis. MiRNAs represent a valuable tool for diagnosing and monitoring of cardiovascular disease.
This paper will give an overview of the current developmental progression of RNA therapeutics as a holistic approach for treating cardiovascular diseases in different animal models and clinical trials. Future interrogations are warranted for the development of miRNA-based therapeutics to overcome challenges for the treatment of the disease
Publication
Mohammed Rabiul Hosen, Philip Roger Goody, Andreas Zietzer, Georg Nickenig, and Felix Jansen
MicroRNAs As Master Regulators of Atherosclerosis: From Pathogenesis to Novel Therapeutic Options; Antioxidants & Redox Signaling; 8 Jun 2020; https://doi.org/10.1089/ars.2020.8107