Link to the podcast: https://www.ahajournals.org/circ/podcasts
Information about the podcast
Circulation January 24, 2023 Issue
Released: Jan 23, 2023
Please join author Subodh Verma and Guest Editor Christopher Granger as they discuss the article "Empagliflozin and Left Ventricular Remodeling in People Without Diabetes: Primary Results of the EMPA-HEART 2 CardioLink-7 Randomized Clinical Trial."
Publication
Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB 4th, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F. Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Circulation. 2022 Jul 8:101161CIRCULATIONAHA122060258. doi: 10.1161/CIRCULATIONAHA.122.060258
Summary of the Publication
This study investigated the association between the level of a specific microRNA (miRNA-122-5p) in the bloodstream and the improvement in left ventricular function after transcatheter aortic valve replacement (TAVR) surgery. The study found that patients with higher levels of miRNA-122-5p in their blood did not show as much improvement in left ventricular function after TAVR surgery compared to patients with lower levels of the miRNA. Additionally, the study discovered that miRNA-122-5p regulates the viability of cardiomyocytes (heart muscle cells) through extracellular vesicles. The study's authors suggest that measuring the level of miRNA-122-5p in the blood could be used as a biomarker to predict which patients are less likely to benefit from TAVR surgery, and that targeting miRNA-122-5p may be a potential therapeutic approach to improve outcomes after TAVR.