B05 - Necroptosis in aortic aneurysm disease - significance of inflammation in MLKL dependent cell death
Regulated cell death of aortic smooth muscle cells represents a hallmark of aortic aneurysm formation. In the first funding period, we have shown that the mixed lineage kinase-like pseudokinase (MLKL)-dependent inhibition of necroptosis, a specific form of regulated cell death, mitigates abdominal aortic aneurysm disease in mice. To underline the translational potential of these findings, we now aim to establish a large animal model of pharmaceutical MLKL inhibition in pigs. Additionally, we will characterise the impact of MLKL-dependent necroptosis-inhibition on models of thoracic aortic aneurysm disease, a condition connected with Marfan’s syndrome and driven by dysregulation of cell death and matrix formation and thereby a very promising target for MLKL-alteration.
![B05.png](https://www.trr259.uni-bonn.de/en/bilder-trr259/2-funding-period-projektubersichten/b05.png/@@images/image/leadimagesize)
Contacts
Prof. Ana J. García Sáez
Cluster of Excellence for Aging Research (CECAD) Research Center
University of Cologne
Joseph-Stelzmann-Str. 26
50931 Cologne
PD Dr. Matti Adam
Department of Internal Medicine III
University Hospital Cologne
Kerpener Str. 62
50937 Köln
Dr. Martin Mollenhauer
Department III for Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne
Dr. Henning Guthoff
Herzzentrum
Kerpenerstr. 62
50937 Köln
Department III for Internal Medicine
Dr. Dennis Mehrkens
Department III for Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne
Dr. Harshal Nemade
Lehre, Forschung, Information (LFI), Building 13, 4th floor, room 105
Department III for Internal Medicine
Experimental Cardiology
University Hospital Cologne
Kerpener Str. 62
50937 Cologne
Christina Schroth
Department III of Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne
Simon Grimm
Department III of Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne