B05 - Necroptosis in aortic aneurysm disease - significance of inflammation in MLKL dependent cell death

Regulated cell death of aortic smooth muscle cells represents a hallmark of aortic aneurysm formation. In the first funding period, we have shown that the mixed lineage kinase-like pseudokinase (MLKL)-dependent inhibition of necroptosis, a specific form of regulated cell death, mitigates abdominal aortic aneurysm disease in mice. To underline the translational potential of these findings, we now aim to establish a large animal model of pharmaceutical MLKL inhibition in pigs. Additionally, we will characterise the impact of MLKL-dependent necroptosis-inhibition on models of thoracic aortic aneurysm disease, a condition connected with Marfan’s syndrome and driven by dysregulation of cell death and matrix formation and thereby a very promising target for MLKL-alteration.

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© Sebastian Zimmer

Contacts

Avatar García Sáez

Prof. Ana J. García Sáez

Project leader B05

Cluster of Excellence for Aging Research (CECAD) Research Center

University of Cologne

Joseph-Stelzmann-Str. 26

50931 Cologne

Avatar Adam

PD Dr. Matti Adam

Project leader B05

Department of Internal Medicine III

University Hospital Cologne

Kerpener Str. 62

50937 Köln

Avatar Mollenhauer

Dr. Martin Mollenhauer

Postdoc

Department III for Internal Medicine

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

Avatar Guthoff

Dr. Henning Guthoff

Postdoc

Herzzentrum

Kerpenerstr. 62

50937 Köln

Department III for Internal Medicine

Avatar Mehrkens

Dr. Dennis Mehrkens

Postdoc

Department III for Internal Medicine

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

Avatar Nemade

Dr. Harshal Nemade

Postdoc

Lehre, Forschung, Information (LFI), Building 13, 4th floor, room 105

Department III for Internal Medicine

Experimental Cardiology

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

Avatar Schroth

Christina Schroth

Technical Assistant

Department III of Internal Medicine

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

Avatar Grimm

Simon Grimm

Technical Assistant

Department III of Internal Medicine

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

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