B10-Sphingosine-1-phosphate (S1P) signalling in aortic aneurysm formation and dissection
We will characterise the causal role of the bioactive lipid S1P in aneurysm formation, progression and dissection. We will use pharmacological and genetic approaches to identify the S1P receptors and signalling pathways that promote or alleviate the disease. In a translational approach, we will define sphingolipid-based risk scores for patients with aneurysms using modern targeted lipidomics. Finally, we will test the potential of already approved S1P-based drugs to prevent aneurysm formation and progression in preclinical models and potentially in humans.
Contacts
Prof. Bodo Levkau
Building 22.03., 6th floor
Institute for Molecular Medicine III
University Hospital Düsseldorf
Institut für Molekulare Medizin III
40225 Düsseldorf
Nathalie H. Schröder
Building 22.03., 6th floor
Institute for Molecular Medicine III
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf
Dr. Petra Keul
Building 22.03., 6th floor
Institute for Molecular Medicine III
40225 Düsseldorf
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf
Dr. Philipp Wollnitzke
Building 22.03., 6th floor
Institute for Molecular Medicine III
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf
Dr. Dragos Andrei Duse
Building 22.03., 6th floor
Institute for Molecular Medicine III
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf