B10-Sphingosine-1-phosphate (S1P) signalling in aortic aneurysm formation and dissection

We will characterise the causal role of the bioactive lipid S1P in aneurysm formation, progression and dissection. We will use pharmacological and genetic approaches to identify the S1P receptors and signalling pathways that promote or alleviate the disease. In a translational approach, we will define sphingolipid-based risk scores for patients with aneurysms using modern targeted lipidomics. Finally, we will test the potential of already approved S1P-based drugs to prevent aneurysm formation and progression in preclinical models and potentially in humans.