C02-The role of local and systemic haemodynamic forces and inflammatory patterns in the development of aortic disease
Up to now, we have established novel multimodal, segmentally applicable magnetic resonance imaging (MRI) techniques for a comprehensive functional/structural phenotyping of the entire aorta. In mice with aortic stenosis (AS), we identified subtle adaptations for demarcation of disease transition, which will allow early interventional studies to explore incipient disease pathophysiology. In experimental models of abdominal aortic aneurysms (AAA), we were able to monitor the profound immune cell influx by molecular 19F MRI. In humans, we observed site-specific patterns of aortic dysfunction which are heterotopically affected by large artery stiffening (LAS).
Now, we will calculate and map novel multiparametric and molecular MRI metrics to detect specific danger patterns for the onset of aortic disease and the progression of aortic malfunction and heterotopic maladaptation in small and large animals and humans.
Contacts
Dr. Christine Quast
Division of Cardiology, Pulmonology and Vascular Medicine
University Hospital Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Prof. Dr. Ulrich Flögel
Building 22.04.00, room 68
Experimental Cardiovascular Imaging
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf
Prof. Dr. Verena Hörr
Medical Clinic and Polyclinic II
Cardiovascular Imaging Research Group
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Ali Nahardani
Medical Clinic and Polyclinic II
Cardiovascular Imaging Research Group
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Magdalena Nankinova
Division of Cardiology, Pulmonology and Vascular Medicine
University Hospital Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Dr. Pascal Bouvain
Building 22.04.00, room 60
Experimental Cardiovascular Imaging
University Hospital Düsseldorf
Universitätsstraße 1
40225 Düsseldorf