C02-The role of local and systemic haemodynamic forces and inflammatory patterns in the development of aortic disease

Up to now, we have established novel multimodal, segmentally applicable magnetic resonance imaging (MRI) techniques for a comprehensive functional/structural phenotyping of the entire aorta. In mice with aortic stenosis (AS), we identified subtle adaptations for demarcation of disease transition, which will allow early interventional studies to explore incipient disease pathophysiology. In experimental models of abdominal aortic aneurysms (AAA), we were able to monitor the profound immune cell influx by molecular 19F MRI. In humans, we observed site-specific patterns of aortic dysfunction which are heterotopically affected by large artery stiffening (LAS).

Now, we will calculate and map novel multiparametric and molecular MRI metrics to detect specific danger patterns for the onset of aortic disease and the progression of aortic malfunction and heterotopic maladaptation in small and large animals and humans.

C02.png
© Sebastian Zimmer

Contacts

Avatar Quast

Dr. Christine Quast

Project leader C02

Division of Cardiology, Pulmonology and Vascular Medicine

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Flögel

Prof. Dr. Ulrich Flögel

Project leader C02

Building 22.04.00, room 68

Experimental Cardiovascular Imaging

University Hospital Düsseldorf

Universitätsstraße 1

40225 Düsseldorf

Avatar Hörr

Prof. Dr. Verena Hörr

Project leader C02

Medical Clinic and Polyclinic II

Cardiovascular Imaging Research Group

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Nahardani

Dr. Ali Nahardani

Postdoc

Medical Clinic and Polyclinic II

Cardiovascular Imaging Research Group

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Nankinova

Magdalena Nankinova

Postdoc

Division of Cardiology, Pulmonology and Vascular Medicine

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Bouvain

Dr. Pascal Bouvain

Postdoc

Building 22.04.00, room 60

Experimental Cardiovascular Imaging

University Hospital Düsseldorf

Universitätsstraße 1

40225 Düsseldorf

Wird geladen