C05-GUARD – Genes Underlying Aortic valve Disease

Aortic valve stenosis (AS) develops in the context of a bi- or tricuspid aortic valve formation. Genetic factors are involved in the development of both AS types. However, the genetic architecture is heterogeneous and depends on the effect size and frequency of the underlying disease variants/mutations. Through our scientific network GUARD (www.guard-net.de), we carried out two large genome-wide association studies (GWAS) that led to the identification of common risk variants for the development of both AS types. We now aim to identify the entire spectrum of genetic risk factors for bi- and tricuspid AS and to analyse them together with other disease-relevant data sets using modern systems biology approaches.

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© Sebastian Zimmer

Contacts

Avatar Nöthen

Prof. Dr. Markus M. Nöthen

Project leader C05

Biomedical Center I, Building 13, ground floor

Institute of Human Genetics

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Billmann

Jun.-Prof. Dr. Maximilian Billmann

Project leader C05

Building 76

Institute of Human Genetics

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Al-Kassou

PD Dr. Baravan Al-Kassou

Project leader C05

Building 26

Medical Clinic and Polyclinic II

Heart Center

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Schumacher

Prof. Dr. Johannes Schumacher

Project leader B07

Center for Human Genetics

Philipps-University Marburg

Baldingerstraße

35033 Marburg

Avatar Grover

Dr. Sandeep Grover

Postdoc C05

Institut for Human Genetics

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

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