C06-Biomarkers and mechanisms of disease progression and outcome in aortic stenosis in humans
Early recognition and management of aortic stenosis (AS) are substantial to avoid life-threatening events during the clinical course. Complex mechanisms including fibrosis, oxidative stress, inflammation, angiogenesis, osteogenic differentiation and the effect of genetic risk variants have been proposed to be involved mechanistically in the pathogenesis of degenerative AS. In our project, we plan to assess multiple morphological, functional, genetic and immunological parameters and combine these parameters for model development, applying deep learning algorithms, to investigate their capacity to predict disease progression in patients with moderate AS in a longitudinal long-term clinical study.
![C06N.png](https://www.trr259.uni-bonn.de/en/bilder-trr259/2-funding-period-projektubersichten/c06n.png/@@images/image/large)
Contacts
Prof. Dr. Bernardo Franklin
Biomedical Center II, Building 12, 2nd floor
Institute of Innate Immunity
Cellular Immunology & Infection Research Group
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Prof. Dr. Tobias Zeus
Clinic for Cardiology, Pneumology and Angiology
University Hospital Düsseldorf
Moorenstraße 5
40225 Düsseldorf
PD Dr. Victor Mauri
Clinic III for Internal Medicine
University Hospital Cologne
Kerpener Str. 62
50937 Cologne
Dr. Jasmin Shamekhi
Building 26
Medical Clinic and Polyclinic II
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
PD Dr. Julian Luetkens
Clinic for Diagnostic and Interventional Radiology
Quantitative Imaging Lab
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Dr. Ibrahim Hawwari
Institute of Innate Immunity
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn