C06-Biomarkers and mechanisms of disease progression and outcome in aortic stenosis in humans

Early recognition and management of aortic stenosis (AS) are substantial to avoid life-threatening events during the clinical course. Complex mechanisms including fibrosis, oxidative stress, inflammation, angiogenesis, osteogenic differentiation and the effect of genetic risk variants have been proposed to be involved mechanistically in the pathogenesis of degenerative AS. In our project, we plan to assess multiple morphological, functional, genetic and immunological parameters and combine these parameters for model development, applying deep learning algorithms, to investigate their capacity to predict disease progression in patients with moderate AS in a longitudinal long-term clinical study.

 

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© Sebastian Zimmer

Contacts

Avatar Franklin

Prof. Dr. Bernardo Franklin

Project leader C06

Biomedical Center II, Building 12, 2nd floor

Institute of Innate Immunity

Cellular Immunology & Infection Research Group

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Zeus

Prof. Dr. Tobias Zeus

Project leader C06

Clinic for Cardiology, Pneumology and Angiology

University Hospital Düsseldorf

Moorenstraße 5

40225 Düsseldorf

Avatar Mauri

PD Dr. Victor Mauri

Project leader C06

Clinic III for Internal Medicine

University Hospital Cologne

Kerpener Str. 62

50937 Cologne

Avatar Shamekhi

Dr. Jasmin Shamekhi

Project leader C06

Building 26

Medical Clinic and Polyclinic II

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Luetkens

PD Dr. Julian Luetkens

Project leader C06

Clinic for Diagnostic and Interventional Radiology

Quantitative Imaging Lab

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Avatar Hawwari

Dr. Ibrahim Hawwari

Postdoc

Institute of Innate Immunity

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

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