TRR259 - Aortic Disease
University of Bonn
TRR259 - Aortic Disease
University of Cologne
TRR259 - Aortic Disease
University of Düsseldorf
TRR259 - Aortic Disease
TRR259 - Aortic Disease
TRR259 - Aortic Disease

Publications of the TRR259 - 2021

Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides

Zietzer A, Jahnel AL, Bulic M, Gutbrod K, Düsing P, Hosen MR, Dörmann P, Werner N, Nickenig G, Jansen F. 

Cell Mol Life Sci. 2021 Dec 24. doi: 10.1007/s00018-021-04049-5. Epub ahead of print. PMID: 34951654.

Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome

Pottie L, Adamo CS, Beyens A, Lütke S, Tapaneeyaphan P, De Clercq A, Salmon PL, De Rycke R, Gezdirici A, Gulec EY, Khan N, Urquhart JE, Newman WG, Metcalfe K, Efthymiou S, Maroofian R, Anwar N, Maqbool S, Rahman F, Altweijri I, Alsaleh M, Abdullah SM, Al-Owain M, Hashem M, Houlden H, Alkuraya FS, Sips P, Sengle G, Callewaert B

Am J Hum Genet. 2021 Dec 2;108(12):2386-2388. doi: 10.1016/j.ajhg.2021.11.009.

Acute Heart Failure After Reperfused Ischemic Stroke: Association With Systemic and Cardiac Inflammatory Responses

Vornholz L, Nienhaus F, Gliem M, et al.

Front Physiol. 2021;12:2299. doi:10.3389/fphys.2021.782760

MicroRNA-Based Diagnostics in Heart Diseases

Düsing P, Zietzer A, Jansen F.

JACC Basic to Transl Sci. 2021;6(11):897-899. doi:10.1016/J.JACBTS.2021.08.004

Temporal trends of TAVI treatment characteristics in high volume centers in Germany 2013-2020.

Mauri V, Abdel-Wahab M, Bleiziffer S, Veulemans V, Sedaghat A, Adam M, Nickenig G, Kelm M, Thiele H, Baldus S, Rudolph TK.

Clin Res Cardiol. 2021 Nov 9. doi: 10.1007/s00392-021-01963-3. Epub ahead of print. PMID: 34751789.

Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

Winkels H, Ghosheh Y, Kobiyama K, Kiosses WB, Orecchioni M, Ehinger E, Suryawanshi V, Herrera-De La Mata S, Marchovecchio P, Riffelmacher T, Thiault N, Kronenberg M, Wolf D, Seumois G, Vijayanand P, Ley K. .

J Immunol. 2021 Nov 5:ji2100208. doi: 10.4049/jimmunol.2100208. Epub ahead of print. PMID: 34740961.

NcRNAs in Vascular and Valvular Intercellular Communication

Bartsch B, Goody P R , Hosen M R, Nehl D, Mohammadi N, Zietzer A, Düsing P, Pfeifer A, Nickenig G, Jansen F,

Front Mol Biosci. 2021 Nov 5;8:749681. doi: 10.3389/fmolb.2021.749681. PMID: 34805273; PMCID: PMC8602872.

 Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens

Kleiner JL, Köpke O, Faron A, Zhang Y, Cornelssen J, Coburn M, Frede S, Eichhorn L, Weisheit CK

Mediators Inflamm. 2021 Nov 3;2021:1376859. doi: 10.1155/2021/1376859.

Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice.

Böhner AMC, Jacob AM, Heuser C, Stumpf NE, Effland A, Abdullah Z, Meyer-Schwesiger C, von Vietinghoff S, Kurts C

J Am Soc Nephrol. 2021 Oct;32(10):2445-2453. doi: 10.1681/ASN.2021010110. Epub 2021 Jun 18. PMID: 34599036; PMCID: PMC8722799.

Beyond Vessel Diameters: Non-invasive Monitoring of Flow Patterns and Immune Cell Recruitment in Murine Abdominal Aortic Disorders by Multiparametric MRI

Temme S, Yakoub M, Bouvain P, Yang G, Schrader J, Stegbauer J, Flögel U.

Front Cardiovasc Med. 2021 Oct 25;8:750251. doi: 10.3389/fcvm.2021.750251. PMID: 34760945; PMCID: PMC8572976.

Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation

Mollenhauer M, Bokredenghel S, Geißen S, Klinke A, Morstadt T, Torun M, Strauch S, Schumacher W, Maass M, Konradi J, Peters VBM, Berghausen E, Vantler M, Rosenkranz S, Mehrkens D, Braumann S, Nettersheim F, Hof A, Simsekyilmaz S, Winkels H, Rudolph V, Baldus S, Adam M, Freyhaus HT

Front Immunol. 2021 Oct 6;12:701721. doi: 10.3389/fimmu.2021.701721. PMID: 34691017; PMCID: PMC8527169

Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders

Flögel U, Temme S, Jacoby C, Oerther T, Keul P, Flocke V, Wang X, Bönner F, Nienhaus F, Peter K, Schrader J, Grandoch M, Kelm M, Levkau B.

Nat Commun. 2021 Oct 6;12(1):5847. doi: 10.1038/s41467-021-26146-6. PMID: 34615876; PMCID: PMC8494909

ESC/EACTS guidelines 2021 on the management of valvular heart diseases : What are the most important innovations?

Nettersheim FS, Baldus S

Herz 2021. Published online October 5, 2021:1-12. doi:10.1007/S00059-021-05068-5

Disrupted PI3K subunit p110α signaling protects against pulmonary hypertension and reverses established disease in rodents

Berghausen EM, Janssen W, Vantler M, Gnatzy-Feik LL, Krause M, Behringer A, Joseph C, Zierden M, Freyhaus HT, Klinke A, Baldus S, Alcazar MA, Savai R, Pullamsetti SS, Wong DW, Boor P, Zhao JJ, Schermuly RT, Rosenkranz S.

J Clin Invest. 2021 Oct 1;131(19):e136939. doi: 10.1172/JCI136939. PMID: 34596056; PMCID: PMC8483754.

Peri-Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm

Mulorz J, Shayan M, Hu C, Alcazar C, Chan AHP, Briggs M, Wen Y, Walvekar AP, Ramasubramanian AK, Spin JM, Chen B, Tsao PS, Huang NF. .

Biomater Sci. 2021 Sep 15. doi: 10.1039/d1bm00685a. Epub ahead of print. PMID: 34522940

Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice

Zimmer S, Goody PR, Oelze M, Ghanem A, Mueller CF, Laufs U, Daiber A, Jansen F, Nickenig G, Wassmann S.

Front Cardiovasc Med. 2021 Aug 6;8:680775. doi: 10.3389/fcvm.2021.680775. PMID: 34422919; PMCID: PMC8377253.

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G.

Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211. PMID: 34502122; PMCID: PMC8431127

Gimme' the Loop: Modifications to the Squid-Capture Technique for Laser-Fenestrated Thoracic Endografting

Mulorz J, Knapsis A, Ertas N, Schelzig H, Wagenhäuser MU. 

J Endovasc Ther. 2021 Aug;28(4):524-529. doi: 10.1177/15266028211007475. Epub 2021 Apr 15. PMID: 33855878; PMCID: PMC8276338.

Nitro-Oleic Acid (NO 2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Braumann S, Schumacher W, Im NG, Nettersheim FS, Mehrkens D, Bokredenghel S, Hof A, Nies RJ, Adler C, Winkels H, Knöll R, Freeman BA, Rudolph V, Klinke A, Adam M, Baldus S, Mollenhauer M, Geißen S. 

Int J Mol Sci. 2021 Aug 22;22(16):9052. doi: 10.3390/ijms22169052. PMID: 34445757; PMCID: PMC8396484

Outflow Through Aortic Side Branches Drives False Lumen Patency in Type B Aortic Dissection

Gerlinde Logghe, Bram Trachet, Patrick Segers, Julie De Backer, Joscha Mulorz, Philip Düppers, Frank Vermassen, Hubert Schelzig, Isabelle van Herzeele, Markus Udo Wagenhäuser.

Front Cardiovasc Med. 2021 Aug 13;0:822. doi:10.3389/FCVM.2021.710603

Nitro-oleic acid (NO2-OA) reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome

Nettersheim FS, Lemties J, Braumann S, Geißen S, Bokredenghel S, Nies R, Hof A, Winkels H, Freeman BA, Klinke A, Rudolph V, Baldus S, Mehrkens D, Mollenhauer M, Adam M.

Cardiovasc Res. 2021 Jul 29:cvab256. doi: 10.1093/cvr/cvab256. Epub ahead of print. PMID: 34324651

Controlling BMP growth factor bioavailability: The extracellular matrix as multi skilled platform

Zimmermann LA, Correns A, Furlan AG, Spanou CES, Sengle G.

Cell Signal. 2021 Jul 2;85:110071. doi: 10.1016/j.cellsig.2021.110071. Epub ahead of print. PMID: 34217834.

HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence 

Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Übelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmüller J, Georgomanolis T, Mizi A, Papantonis A.

Mol Syst Biol. 2021 Jun;17(6):e9760. doi: 10.15252/msb.20209760. PMID: 34166567; PMCID: PMC8224457.

Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus

Kohlmorgen C, Gerfer S, Feldmann K, Twarock S, Hartwig S, Lehr S, Klier M, Krüger I, Helten C, Keul P, Kahl S, Polzin A, Elvers M, Flögel U, Kelm M, Levkau B, Roden M, Fischer JW, Grandoch M. 

Diabetologia. 2021 Aug;64(8):1834-1849. doi: 10.1007/s00125-021-05498-0. Epub 2021 Jun 16. PMID: 34131781; PMCID: PMC8245397.

Small Blebs, Big Potential — Can Extracellular Vesicles Cure Cardiovascular Disease?

Zietzer, Andreas, Georg Nickenig, and Felix Jansen

European Heart Journal, 2021, https://doi.org/10.1093/eurheartj/ehab334

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Lacy, Michael, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, and others

Nat Commun 12, 3754 (2021). <https://doi.org/10.1038/s41467-021-23909-z>

Bi-Allelic Premature Truncating Variants in LTBP1 Cause Cutis Laxa Syndrome

Lore Pottie, Christin S. Adamo, Aude Beyens, Steffen Lütke, Piyanoot Tapaneeyaphan, Adelbert De Clercq, Phil L. Salmon, Riet De Rycke, Alper Gezdirici, Elif Yilmaz Gulec, Naz Khan, Jill E. Urquhart, William G. Newman, Kay Metcalfe, Stephanie Efthymiou, Reza Maroofian, Najwa Anwar, Shazia Maqbool, Fatima Rahman, Ikhlass Altweijri, Monerah Alsaleh, Sawsan Mohamed Abdullah, Mohammad Al-Owain, Mais Hashem, Henry Houlden, Fowzan S. Alkuraya, Patrick Sips, Gerhard Sengle, Bert Callewaert

The American Journal of Human Genetics, June 3, 2021, 1–20, https://doi.org/10.1016/j.ajhg.2021.04.016>

Coronary Artery Disease Increases the Long Noncoding RNA PUNISHER in Small Extracellular Vesicles and Regulates Endothelial Cell Function via Vesicular Shuttling

Hosen, Mohammed Rabiul, Qian Li, Yangyang Liu, Andreas Zietzer, Katharina Maus, Philip Goody, Shizuka Uchida, Eicke Latz, Nikos Werner, Georg Nickenig, Felix Jansen

Molecular Therapy - Nucleic Acids, 2021 <https://doi.org/10.1016/j.omtn.2021.05.023>

CAD increases the long noncoding RNA PUNISHER in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling

Hosen MR, Li Q, Liu Y, Zietzer A, Maus K, Goody P, Uchida S, Latz E, Werner N, Nickenig G, Jansen F 

Mol Ther Nucleic Acids. 2021 Jun 4;25:388-405. doi: 10.1016/j.omtn.2021.05.023.

Large Extracellular Vesicles in the Left Atrial Appendage in Patients with Atrial Fibrillation—the Missing Link?

Andreas Zietzer, Baravan Al-Kassou, Paul Jamme, Eva Steffen, Marko Bulic, Mohammed Rabiul Hosen, Philip Roger Goody, Vedat Tiyerili, Sebastian Zimmer, Jan Wilko Schrickel, Alexander Sedaghat, Nikos Werner, Georg Nickenig & Felix Jansen

Clin Res Cardiol, 2021 Jun 1. https://doi.org/10.1007/s00392-021-01873-4

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.

Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A.

Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1. PMID: 34021162; PMCID: PMC8140133.

Regulation and function of CX3CR1 and its ligand CX3CL1 in kidney disease

von Vietinghoff S, Kurts C.

Cell Tissue Res. 2021 May 19. doi: 10.1007/s00441-021-03473-0

The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication

Kargapolova, Yulia, Simon Geißen, Ruiyuan Zheng, Stephan Baldus, Holger Winkels, Matti Adam

Antioxidants, 2021 Apr 5;10(4):562. https://doi.org/10.3390/antiox10040562

Incidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement

Mauri, Victor, Kevin Reuter, Maria I Körber, Hendrik Wienemann, Samuel Lee, Kaveh Eghbalzadeh, Elmar Kuhn, Baldus Stephan, Kelm Malte, Nickenig Georg, Veulemans Verena, Jansen Felix, Adam Matti, Rudolph Tanja K

Frontiers in Cardiovascular Medicine, 2021 Mar 26,8, 229, https://doi.org/10.3389/fcvm.2021.645724

A new MMP-mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix

Furlan AG, Spanou CES, Godwin ARF, Wohl AP, Zimmermann LA, Imhof T, Koch M, Baldock C, Sengle G.

FASEB J. 2021 Mar;35(3):e21353. doi: 10.1096/fj.202001264R. PMID: 33629769

Smartphone-guided secondary prevention for patients with coronary artery disease

Eckardt I, Buschhaus C, Nickenig G, Jansen F.

J Rehabil Assist Technol Eng. 2021 Mar 16;8:2055668321996572. doi: 10.1177/2055668321996572. PMID: 33796334; PMCID: PMC7970225.

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Winkels H, Wolf D

Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):549-563. doi: 10.1161/ATVBAHA.120.312137

3D-speckle-tracking echocardiography correlates with CMR diagnosis of acute myocarditis

Philip Goody, Sebastian Zimmer, Angela Zimmer, Jens Kreuz, Marc Ulrich Becher, Alexander Isaak, Georg Nickenig, Christoph Hammerstingl, Vedat Tiyerili

Authorea. February 17, 2021

Phenotyping placental oxygenation in Lgals1 deficient mice using 19F MRI

Boehm-Sturm P, Mueller S, Freitag N, Borowski S, Foddis M, Koch SP, Temme S, Flögel U, Blois SM. 

Sci Rep. 2021 Jan 22;11(1):2126. doi: 10.1038/s41598-020-80408-9. PMID: 33483548; PMCID: PMC7822814.

Vancomycin and Daptomycin Modulate the Innate Immune Response in a Murine Model of LPS-Induced Sepsis

Muenster, Stefan, Valentina Zschernack, Birte Dierig, Stilla Frede, Georg Baumgarten, Mark Coburn, Christian Putensen and Christina Weisheit

International Journal of Immunopathology and Pharmacology, 35 (Jan. 2021), doi:10.1177/20587384211031373

Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation

 Misiou, Angelina, James C. Garmey, Jack M. Hensien, Daniel B. Harmon, Victoria Osinsk, Chantel McSkimming, Melissa A. Marshall, Jens W. Fischer, Maria Grandoch, Coleen A. McNamara

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Dec 31, 41, 796–807; https://doi.org/10.1161/atvbaha.120.315588

CX3CR1 Is a Prerequisite for the Development of Cardiac Hypertrophy and Left Ventricular Dysfunction in Mice upon Transverse Aortic Constriction

Weisheit, Christina Katharina, Jan Lukas Kleiner, Maria Belen Rodrigo, Sven Thomas Niepmann, Sebastian Zimmer, Georg Daniel Duerr, Mark Coburn, Christian Kurts, Stilla Frede, and Lars Eichhorn.

PLoS One. 2021 Jan 7; 16(1):e0243788. doi: 10.1371/journal.pone.0243788

Vaskuläre Inflammation: Interaktion zwischen ECM und Immunzellen

Zimmermann L-M, Mehrkens D, Baldus S, Sengle G.

Trillium, 1/2020

Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches

Philip Düsing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen.

J Mol Med, 2021 Jan 22. https://doi.org/10.1007/s00109-021-02037-7

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